Cordon-Bleu Is an Actin Nucleation Factor and Controls Neuronal Morphology

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Cordon-Bleu Is an Actin Nucleation Factor and Controls Neuronal Morphology

Despite the wealth of different actin structures formed, only two actin nucleation factors are well established in vertebrates: the Arp2/3 complex and formins. Here, we describe a further nucleator, cordon-bleu (Cobl). Cobl is a brain-enriched protein using three Wiskott-Aldrich syndrome protein homology 2 (WH2) domains for actin binding. Cobl promotes nonbundled, unbranched filaments. Filament...

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Cordon-Bleu: A New Taste in Actin Nucleation

Polymerization of actin filaments powers many dynamic cellular events and is directed by a small group of actin nucleators. In this issue, Ahuja et al. (2007) identify and characterize a new actin nucleator called cordon-bleu (Cobl) that may drive morphogenesis of the central nervous system during development.

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Cordon-Bleu uses WH2 domains as multifunctional dynamizers of actin filament assembly.

Cordon-Bleu is, like Spire, a member of the growing family of WH2 repeat proteins, which emerge as versatile regulators of actin dynamics. They are expressed in morphogenetic and patterning processes and nucleate actin assembly in vitro. Here, we show that Cordon-Bleu works as a dynamizer of actin assembly by combining many properties of profilin with weak filament nucleating and powerful filam...

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ژورنال

عنوان ژورنال: Cell

سال: 2007

ISSN: 0092-8674

DOI: 10.1016/j.cell.2007.08.030